Assay Detail
ADMET
CHEMBL856822
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Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.41 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221398 | — | — | 1 | 6.96 |
| CHEMBL218155 | — | — | 1 | 6.92 |
| CHEMBL221813 | — | — | 1 | 6.89 |
| CHEMBL218011 | — | — | 1 | 6.89 |
| CHEMBL218012 | — | — | 1 | 6.70 |
| CHEMBL221550 | — | — | 1 | 6.62 |
| CHEMBL218296 | — | — | 1 | 6.58 |
| CHEMBL426715 | — | — | 1 | 6.58 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.57 |
| CHEMBL373503 | — | — | 1 | 6.35 |
| CHEMBL374672 | — | — | 1 | 6.28 |
| CHEMBL384135 | — | — | 1 | 6.26 |
| CHEMBL218245 | — | — | 1 | 6.24 |
| CHEMBL217980 | — | — | 1 | 6.17 |
| CHEMBL387450 | — | — | 1 | 6.16 |
| CHEMBL374570 | — | — | 1 | 5.91 |
| CHEMBL219325 | — | — | 1 | 5.87 |
| CHEMBL219326 | — | — | 1 | 5.87 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 5.84 |
| CHEMBL374765 | — | — | 1 | 5.73 |
| CHEMBL221022 | — | — | 1 | 5.72 |
| CHEMBL219381 | — | — | 1 | 5.71 |
| CHEMBL221298 | — | — | 1 | 5.65 |
| CHEMBL221631 | — | — | 1 | 5.58 |
| CHEMBL15193 | LAPACHOL | — | 1 | 5.50 |
| CHEMBL221644 | — | — | 1 | 5.50 |
| CHEMBL219541 | — | — | 1 | 5.35 |
| CHEMBL219379 | — | — | 1 | 5.09 |
| CHEMBL218376 | — | — | 1 | 4.94 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221398 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL218155 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL218011 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL221813 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL218012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL221550 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL218296 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL426715 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL373503 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL374672 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL384135 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL218245 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL217980 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL387450 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL374570 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL219325 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL219326 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL374765 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL221022 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL219381 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL221298 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL221631 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL221644 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL219541 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL219379 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL218376 | — | IC50 | = | 11440.0 | nM | 4.94 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 13460.0 | nM | 4.87 |
| CHEMBL218501 | — | IC50 | = | 13390.0 | nM | 4.87 |
| CHEMBL220804 | — | IC50 | = | 15530.0 | nM | 4.81 |
| CHEMBL222073 | — | IC50 | = | 22910.0 | nM | 4.64 |
| CHEMBL448792 | — | IC50 | = | 23680.0 | nM | 4.63 |
| CHEMBL386074 | — | IC50 | = | 24160.0 | nM | 4.62 |
| CHEMBL221023 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL376845 | — | IC50 | = | 26260.0 | nM | 4.58 |
| CHEMBL374724 | — | IC50 | = | 27740.0 | nM | 4.56 |
| CHEMBL218095 | — | IC50 | = | 28250.0 | nM | 4.55 |
| CHEMBL221148 | — | IC50 | = | 29660.0 | nM | 4.53 |
| CHEMBL425282 | — | IC50 | = | 31880.0 | nM | 4.50 |
| CHEMBL220648 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL221076 | — | IC50 | = | 44080.0 | nM | 4.36 |
| CHEMBL274625 | — | IC50 | = | 46970.0 | nM | 4.33 |
| CHEMBL221548 | — | IC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL220588 | — | IC50 | = | 48120.0 | nM | 4.32 |
| CHEMBL220649 | — | IC50 | = | 53910.0 | nM | 4.27 |
| CHEMBL155771 | — | IC50 | = | 62130.0 | nM | 4.21 |
| CHEMBL221680 | — | IC50 | = | 68250.0 | nM | 4.17 |
| CHEMBL221440 | — | IC50 | = | 100000.0 | nM | 4.00 |