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Assay Detail

CHEMBL856951

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Subcellular Membrane
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor B (CHEMBL263)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin II receptor antagonists
Hirata T, Goto S, Tamura K, Okuhira M, Nagao Y
Bioorg Med Chem Lett (1997) 7 : 385 -388
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 30 7.53 9.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35381 1 9.21
CHEMBL340863 1 8.70
CHEMBL340618 1 8.60
CHEMBL127988 1 8.57
CHEMBL127090 1 8.49
CHEMBL287116 1 8.47
CHEMBL340304 1 8.46
CHEMBL127068 1 8.41
CHEMBL264003 1 8.22
CHEMBL127343 1 8.14
CHEMBL127332 1 7.82
CHEMBL126643 1 7.75
CHEMBL129181 1 7.66
CHEMBL130530 1 7.55
CHEMBL127002 1 7.45
CHEMBL286537 1 7.44
CHEMBL126351 1 7.32
CHEMBL541992 1 7.31
CHEMBL126490 1 7.10
CHEMBL340518 1 6.99
CHEMBL127605 1 6.87
CHEMBL421092 1 6.85
CHEMBL126801 1 6.85
CHEMBL338670 1 6.72
CHEMBL128003 1 6.70
CHEMBL341292 1 6.52
CHEMBL339120 1 6.50
CHEMBL340662 1 6.48
CHEMBL341109 1 6.35
CHEMBL125964 1 6.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35381 Ki = 0.6194 nM 9.21
CHEMBL340863 Ki = 2.0 nM 8.70
CHEMBL340618 Ki = 2.5 nM 8.60
CHEMBL127988 Ki = 2.692 nM 8.57
CHEMBL127090 Ki = 3.228 nM 8.49
CHEMBL287116 Ki = 3.388 nM 8.47
CHEMBL340304 Ki = 3.467 nM 8.46
CHEMBL127068 Ki = 3.864 nM 8.41
CHEMBL264003 Ki = 5.998 nM 8.22
CHEMBL127343 Ki = 7.244 nM 8.14
CHEMBL127332 Ki = 15.14 nM 7.82
CHEMBL126643 Ki = 17.99 nM 7.75
CHEMBL129181 Ki = 21.98 nM 7.66
CHEMBL130530 Ki = 27.99 nM 7.55
CHEMBL127002 Ki = 35.89 nM 7.45
CHEMBL286537 Ki = 35.97 nM 7.44
CHEMBL126351 Ki = 47.97 nM 7.32
CHEMBL541992 Ki = 48.98 nM 7.31
CHEMBL126490 Ki = 79.43 nM 7.10
CHEMBL340518 Ki = 102.33 nM 6.99
CHEMBL127605 Ki = 133.97 nM 6.87
CHEMBL421092 Ki = 141.25 nM 6.85
CHEMBL126801 Ki = 141.25 nM 6.85
CHEMBL338670 Ki = 190.11 nM 6.72
CHEMBL128003 Ki = 199.99 nM 6.70
CHEMBL341292 Ki = 299.92 nM 6.52
CHEMBL339120 Ki = 319.89 nM 6.50
CHEMBL340662 Ki = 329.61 nM 6.48
CHEMBL341109 Ki = 446.68 nM 6.35
CHEMBL125964 Ki = 557.19 nM 6.25