Assay Detail
Functional
CHEMBL857024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against murine Peroxisome proliferator activated receptor gamma using transfection assay in CV-1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL2459) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.55 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 9.45 |
| CHEMBL423026 | — | — | 1 | 8.33 |
| CHEMBL434063 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 0.3548 | nM | 9.45 |
| CHEMBL423026 | — | EC50 | = | 4.677 | nM | 8.33 |
| CHEMBL434063 | — | EC50 | = | 13.18 | nM | 7.88 |