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Assay Detail

CHEMBL857056

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Binding
Inhibition against Acetylcholinesterase (AChE)
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Acetylcholinesterase (CHEMBL3198) ↗
Type SINGLE PROTEIN
Organism Mus musculus

Publication

A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
Tong W, Collantes ER, Chen Y, Welsh WJ.
J Med Chem (1996) 39 : 380 -387
PubMed 8558505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 6.65 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56960 — — 1 9.52
CHEMBL299708 — — 1 9.22
CHEMBL54058 — — 1 9.22
CHEMBL126354 — — 1 8.27
CHEMBL59583 — — 1 7.54
CHEMBL106891 — — 1 7.52
CHEMBL55312 — — 1 7.46
CHEMBL55968 — — 1 7.41
CHEMBL127527 — — 1 7.34
CHEMBL56001 — — 1 7.29
CHEMBL340672 — — 1 7.28
CHEMBL55323 — — 1 7.26
CHEMBL340621 — — 1 7.19
CHEMBL299313 — — 1 7.16
CHEMBL56706 — — 1 7.07
CHEMBL54835 — — 1 7.06
CHEMBL333909 — — 1 7.01
CHEMBL56586 — — 1 6.92
CHEMBL57696 — — 1 6.89
CHEMBL127750 — — 1 6.84
CHEMBL56470 — — 1 6.77
CHEMBL298603 — — 1 6.75
CHEMBL55253 — — 1 6.75
CHEMBL340609 — — 1 6.69
CHEMBL55466 — — 1 6.64
CHEMBL123909 — — 1 6.62
CHEMBL126827 — — 1 6.43
CHEMBL419782 — — 1 6.39
CHEMBL294242 — — 1 6.33
CHEMBL55131 — — 1 6.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56960 — IC50 = 0.3006 nM 9.52
CHEMBL299708 — IC50 = 0.5998 nM 9.22
CHEMBL54058 — IC50 = 0.5998 nM 9.22
CHEMBL126354 — IC50 = 5.395 nM 8.27
CHEMBL59583 — IC50 = 28.97 nM 7.54
CHEMBL106891 — IC50 = 29.99 nM 7.52
CHEMBL55312 — IC50 = 34.99 nM 7.46
CHEMBL55968 — IC50 = 38.99 nM 7.41
CHEMBL127527 — IC50 = 46.03 nM 7.34
CHEMBL56001 — IC50 = 51.05 nM 7.29
CHEMBL340672 — IC50 = 52.0 nM 7.28
CHEMBL55323 — IC50 = 54.95 nM 7.26
CHEMBL340621 — IC50 = 63.97 nM 7.19
CHEMBL299313 — IC50 = 69.02 nM 7.16
CHEMBL56706 — IC50 = 84.92 nM 7.07
CHEMBL54835 — IC50 = 87.9 nM 7.06
CHEMBL333909 — IC50 = 97.95 nM 7.01
CHEMBL56586 — IC50 = 119.95 nM 6.92
CHEMBL57696 — IC50 = 130.02 nM 6.89
CHEMBL127750 — IC50 = 144.88 nM 6.84
CHEMBL56470 — IC50 = 169.82 nM 6.77
CHEMBL55253 — IC50 = 179.89 nM 6.75
CHEMBL298603 — IC50 = 179.89 nM 6.75
CHEMBL340609 — IC50 = 205.12 nM 6.69
CHEMBL55466 — IC50 = 230.14 nM 6.64
CHEMBL123909 — IC50 = 239.88 nM 6.62
CHEMBL126827 — IC50 = 369.83 nM 6.43
CHEMBL419782 — IC50 = 410.2 nM 6.39
CHEMBL294242 — IC50 = 469.89 nM 6.33
CHEMBL55131 — IC50 = 529.66 nM 6.28
CHEMBL55014 — IC50 = 559.76 nM 6.25
CHEMBL125578 — IC50 = 659.17 nM 6.18
CHEMBL126304 — IC50 = 769.13 nM 6.11
CHEMBL56079 — IC50 = 799.83 nM 6.10
CHEMBL56368 — IC50 = 879.02 nM 6.06
CHEMBL292440 — IC50 = 939.72 nM 6.03
CHEMBL291918 — IC50 = 1000.0 nM 6.00
CHEMBL301243 — IC50 = 1599.56 nM 5.80
CHEMBL326868 — IC50 = 2999.16 nM 5.52
CHEMBL125571 — IC50 = 3296.1 nM 5.48
CHEMBL340382 — IC50 = 13995.87 nM 4.85
CHEMBL339484 — IC50 = 23988.33 nM 4.62
CHEMBL126457 — IC50 = 38018.94 nM 4.42
CHEMBL127097 — IC50 = 41020.41 nM 4.39
CHEMBL126852 — IC50 = 51999.6 nM 4.28