Assay Detail
Binding
CHEMBL857059
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Inhibitory activity against human Tachykinin receptor 2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.96 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217406 | NEUROKININ A | — | 1 | 8.77 |
| CHEMBL431641 | — | — | 1 | 7.51 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 6.99 |
| CHEMBL103634 | — | — | 1 | 6.97 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 6.61 |
| CHEMBL103939 | — | — | 1 | 6.43 |
| CHEMBL102128 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217406 | NEUROKININ A | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL431641 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 102.33 | nM | 6.99 |
| CHEMBL103634 | — | IC50 | = | 107.15 | nM | 6.97 |
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 245.47 | nM | 6.61 |
| CHEMBL103939 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL102128 | — | IC50 | = | 3467.37 | nM | 5.46 |