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Assay Detail

CHEMBL857060

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Functional
Inhibitory activity against melanoma cell line
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type Melanoma cell
Confidence 1 — Organism
Curated By Expert

Target

Melanoma cell (CHEMBL614126)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.
Wang H, Usui T, Osada H, Ganesan A.
J Med Chem (2000) 43 : 1577 -1585
PubMed 10780915 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.31 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41728 1 5.17
CHEMBL43690 1 4.54
CHEMBL285295 1 4.36
CHEMBL282939 1 4.34
CHEMBL39346 DEMETHOXYFUMITREMORGIN C 2 4.32
CHEMBL40267 1 4.30
CHEMBL290894 1 4.29
CHEMBL40266 1 4.26
CHEMBL290939 1 4.06
CHEMBL290601 1 4.06
CHEMBL433630 1 4.03
CHEMBL287884 1 4.02
CHEMBL277043 1 -
CHEMBL410620 1 -
CHEMBL37438 2 -
CHEMBL41875 1 -
CHEMBL412645 1 -
CHEMBL40235 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41728 IC50 = 6760.83 nM 5.17
CHEMBL43690 IC50 = 28840.32 nM 4.54
CHEMBL285295 IC50 = 43651.58 nM 4.36
CHEMBL282939 IC50 = 45708.82 nM 4.34
CHEMBL39346 DEMETHOXYFUMITREMORGIN C IC50 = 47863.01 nM 4.32
CHEMBL40267 IC50 = 50118.72 nM 4.30
CHEMBL290894 IC50 = 51286.14 nM 4.29
CHEMBL40266 IC50 = 54954.09 nM 4.26
CHEMBL290601 IC50 = 87096.36 nM 4.06
CHEMBL290939 IC50 = 87096.36 nM 4.06
CHEMBL433630 IC50 = 93325.43 nM 4.03
CHEMBL287884 IC50 = 95499.26 nM 4.02
CHEMBL39346 DEMETHOXYFUMITREMORGIN C IC50 > 100000.0 nM -
CHEMBL410620 IC50 > 100000.0 nM -
CHEMBL40235 IC50 > 100000.0 nM -
CHEMBL37438 IC50 > 100000.0 nM -
CHEMBL41875 IC50 > 100000.0 nM -
CHEMBL37438 IC50 > 100000.0 nM -
CHEMBL277043 IC50 > 100000.0 nM -
CHEMBL412645 IC50 > 100000.0 nM -