Assay Detail
Binding
CHEMBL857064
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Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.92 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416523 | — | — | 1 | 9.89 |
| CHEMBL11592 | — | — | 1 | 9.70 |
| CHEMBL11425 | — | — | 1 | 8.20 |
| CHEMBL11265 | — | — | 1 | 7.97 |
| CHEMBL11262 | — | — | 1 | 6.63 |
| CHEMBL417608 | — | — | 1 | 6.29 |
| CHEMBL438755 | — | — | 1 | 5.52 |
| CHEMBL416336 | — | — | 1 | 5.38 |
| CHEMBL275481 | — | — | 1 | 4.80 |
| CHEMBL11409 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416523 | — | IC50 | = | 0.1288 | nM | 9.89 |
| CHEMBL11592 | — | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL11425 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL11265 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL11262 | — | IC50 | = | 234.42 | nM | 6.63 |
| CHEMBL417608 | — | IC50 | = | 512.86 | nM | 6.29 |
| CHEMBL438755 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL416336 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL275481 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL11409 | — | IC50 | = | 15848.93 | nM | 4.80 |