Assay Detail
Binding
CHEMBL857080
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Concentration required for 50% inhibition of binding against human Alpha-1B adrenergic receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.58 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95523 | — | — | 1 | 6.16 |
| CHEMBL319553 | — | — | 1 | 5.75 |
| CHEMBL320419 | — | — | 1 | 5.71 |
| CHEMBL97044 | — | — | 1 | 5.65 |
| CHEMBL421011 | — | — | 1 | 5.23 |
| CHEMBL450018 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95523 | — | IC50 | = | 691.83 | nM | 6.16 |
| CHEMBL319553 | — | IC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL320419 | — | IC50 | = | 1949.84 | nM | 5.71 |
| CHEMBL97044 | — | IC50 | = | 2238.72 | nM | 5.65 |
| CHEMBL421011 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL450018 | — | IC50 | = | 10471.29 | nM | 4.98 |