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Assay Detail

CHEMBL857155

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Binding
Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes
ChEMBL ↗
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Marthasterias glacialis
Cell Type Oocyte
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.
Kunick C, Lauenroth K, Wieking K, Xie X, Schultz C, Gussio R, Zaharevitz D, Leost M, Meijer L, Weber A, Jørgensen FS, Lemcke T.
J Med Chem (2004) 47 : 22 -36
PubMed 14695817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 75 5.84 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331190 — — 1 7.62
CHEMBL299756 PAULLONE 2 — 1 7.62
CHEMBL50894 ALSTERPAULLONE — 1 7.46
CHEMBL325654 — — 1 7.36
CHEMBL121492 — — 1 7.33
CHEMBL333006 — — 1 7.28
CHEMBL118162 — — 1 7.12
CHEMBL119963 — — 1 7.10
CHEMBL325403 — — 1 7.10
CHEMBL333894 — — 1 6.70
CHEMBL319373 — — 1 6.70
CHEMBL100309 — — 1 6.62
CHEMBL419054 — — 1 6.57
CHEMBL328194 — — 1 6.55
CHEMBL98360 — — 1 6.52
CHEMBL121543 — — 1 6.52
CHEMBL119989 — — 1 6.50
CHEMBL333066 — — 1 6.50
CHEMBL329505 — — 1 6.40
CHEMBL296586 KENPAULLONE — 1 6.40
CHEMBL334031 — — 1 6.30
CHEMBL98153 — — 1 6.22
CHEMBL323657 — — 1 6.22
CHEMBL331000 — — 1 6.22
CHEMBL334084 — — 1 6.16
CHEMBL121957 — — 1 6.16
CHEMBL545053 — — 1 6.16
CHEMBL95827 — — 1 6.05
CHEMBL116545 — — 1 6.00
CHEMBL332359 — — 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331190 — IC50 = 23.99 nM 7.62
CHEMBL299756 PAULLONE 2 IC50 = 23.99 nM 7.62
CHEMBL50894 ALSTERPAULLONE IC50 = 34.99 nM 7.46
CHEMBL325654 — IC50 = 43.95 nM 7.36
CHEMBL121492 — IC50 = 46.99 nM 7.33
CHEMBL333006 — IC50 = 52.97 nM 7.28
CHEMBL118162 — IC50 = 74.99 nM 7.12
CHEMBL119963 — IC50 = 79.98 nM 7.10
CHEMBL325403 — IC50 = 79.98 nM 7.10
CHEMBL333894 — IC50 = 199.99 nM 6.70
CHEMBL319373 — IC50 = 199.99 nM 6.70
CHEMBL100309 — IC50 = 239.88 nM 6.62
CHEMBL419054 — IC50 = 269.77 nM 6.57
CHEMBL328194 — IC50 = 279.9 nM 6.55
CHEMBL121543 — IC50 = 299.92 nM 6.52
CHEMBL98360 — IC50 = 299.92 nM 6.52
CHEMBL119989 — IC50 = 319.89 nM 6.50
CHEMBL333066 — IC50 = 319.89 nM 6.50
CHEMBL329505 — IC50 = 399.94 nM 6.40
CHEMBL296586 KENPAULLONE IC50 = 399.94 nM 6.40
CHEMBL334031 — IC50 = 500.03 nM 6.30
CHEMBL98153 — IC50 = 599.79 nM 6.22
CHEMBL323657 — IC50 = 599.79 nM 6.22
CHEMBL331000 — IC50 = 599.79 nM 6.22
CHEMBL545053 — IC50 = 699.84 nM 6.16
CHEMBL121957 — IC50 = 699.84 nM 6.16
CHEMBL334084 — IC50 = 699.84 nM 6.16
CHEMBL95827 — IC50 = 899.5 nM 6.05
CHEMBL116545 — IC50 = 1000.0 nM 6.00
CHEMBL332359 — IC50 = 1199.5 nM 5.92
CHEMBL318911 — IC50 = 1300.17 nM 5.89
CHEMBL120497 — IC50 = 1300.17 nM 5.89
CHEMBL120941 — IC50 = 1300.17 nM 5.89
CHEMBL98554 — IC50 = 1300.17 nM 5.89
CHEMBL318471 — IC50 = 1399.59 nM 5.85
CHEMBL332678 — IC50 = 1399.59 nM 5.85
CHEMBL99037 — IC50 = 1599.56 nM 5.80
CHEMBL317964 — IC50 = 1999.86 nM 5.70
CHEMBL331783 — IC50 = 2197.86 nM 5.66
CHEMBL52551 — IC50 = 2301.44 nM 5.64
CHEMBL316512 — IC50 = 2500.35 nM 5.60
CHEMBL98501 — IC50 = 2999.16 nM 5.52
CHEMBL99803 — IC50 = 2999.16 nM 5.52
CHEMBL329063 — IC50 = 2999.16 nM 5.52
CHEMBL120664 — IC50 = 3198.9 nM 5.50
CHEMBL316940 — IC50 = 3303.7 nM 5.48
CHEMBL119932 — IC50 = 3303.7 nM 5.48
CHEMBL116832 — IC50 = 3698.28 nM 5.43
CHEMBL317150 — IC50 = 3801.89 nM 5.42
CHEMBL118406 — IC50 = 3999.45 nM 5.40