Assay Detail
Binding
CHEMBL857186
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Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A9L |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.58 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553058 | — | — | 1 | 9.30 |
| CHEMBL335542 | — | — | 1 | 9.20 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 7.90 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553058 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL335542 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL21536 | XANOMELINE | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL14 | CARBACHOL | IC50 | = | 12.59 | nM | 7.90 |