Assay Detail
Functional
CHEMBL857231
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In vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.95 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302329 | — | — | 1 | 8.20 |
| CHEMBL304106 | — | — | 1 | 8.00 |
| CHEMBL66441 | — | — | 1 | 8.00 |
| CHEMBL68060 | — | — | 1 | 8.00 |
| CHEMBL441252 | — | — | 1 | 8.00 |
| CHEMBL57993 | — | — | 1 | 8.00 |
| CHEMBL66332 | — | — | 1 | 7.90 |
| CHEMBL67171 | — | — | 1 | 7.90 |
| CHEMBL60504 | — | — | 1 | 7.80 |
| CHEMBL66635 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302329 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL304106 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL66441 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL68060 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL441252 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL57993 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL66332 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL67171 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL60504 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL66635 | — | Kd | = | 19.95 | nM | 7.70 |