Assay Detail
Functional
CHEMBL857236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig trachea
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.96 | 9.50 |
| pA2 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263442 | — | — | 1 | 9.50 |
| CHEMBL30024 | — | — | 1 | 9.40 |
| CHEMBL116852 | — | — | 1 | 9.00 |
| CHEMBL116088 | — | — | 1 | 8.80 |
| CHEMBL119624 | — | — | 1 | 8.20 |
| CHEMBL419224 | — | — | 1 | 7.90 |
| CHEMBL325703 | — | — | 1 | 7.70 |
| CHEMBL117163 | — | — | 1 | 6.70 |
| CHEMBL332609 | — | — | 1 | 6.60 |
| CHEMBL119887 | — | — | 1 | 5.80 |
| CHEMBL324553 | — | — | 1 | - |
| CHEMBL434030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263442 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL30024 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL116852 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL116088 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL119624 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL419224 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL325703 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL117163 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL332609 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL119887 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL324553 | — | pA2 | - | — | - | |
| CHEMBL434030 | — | pA2 | - | — | - |