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Assay Detail

CHEMBL857244

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity against alpha-1 adrenergic receptor of rat anococcygeus muscle; value ranges from 6.2-6.5
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Synthesis and alpha 2-adrenoceptor antagonist activity of some disulfonamidobenzoquinolizines.
Ward TJ, Warrellow GJ, Stirrup JA, Lattimer N, Rhodes KF.
J Med Chem (1989) 32 : 179 -182
PubMed 2562854 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.34 6.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30419 1 6.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30419 Kd = 457.09 nM 6.34