Assay Detail
Functional
CHEMBL857381
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In vitro antiprotozoal activity against Giardia lamblia
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.82 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 7.43 |
| CHEMBL56473 | — | — | 1 | 7.38 |
| CHEMBL293520 | — | — | 1 | 7.19 |
| CHEMBL56234 | — | — | 1 | 7.11 |
| CHEMBL55641 | — | — | 1 | 6.97 |
| CHEMBL56179 | — | — | 1 | 6.90 |
| CHEMBL54544 | — | — | 1 | 6.58 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.91 |
| CHEMBL53788 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL56473 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL293520 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL56234 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL55641 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL56179 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL54544 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL53788 | — | IC50 | = | 1282.0 | nM | 5.89 |