Assay Detail
Binding
CHEMBL857419
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Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.96 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505512 | TAUTOMYCIN | — | 1 | 9.17 |
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 8.93 |
| CHEMBL430266 | CALYCULIN A | — | 1 | 8.92 |
| CHEMBL509059 | CALYCULIN | — | 1 | 8.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505512 | TAUTOMYCIN | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL430266 | CALYCULIN A | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL509059 | CALYCULIN | IC50 | = | 1.49 | nM | 8.83 |