Assay Detail
Binding
CHEMBL857423
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Concentration required for 50% Inhibition of activity against Protein-tyrosine phosphatase Lar
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase F (CHEMBL3521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.39 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338073 | — | — | 1 | 4.39 |
| CHEMBL129681 | — | — | 1 | - |
| CHEMBL341233 | — | — | 1 | - |
| CHEMBL128936 | — | — | 1 | - |
| CHEMBL129918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338073 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL129681 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL341233 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL128936 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL129918 | — | IC50 | = | 2300000.0 | nM | - |