Assay Detail
Binding
CHEMBL857513
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Apparent binding affinity against Dihydrofolate reductase in Escherichia coli
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.21 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418492 | — | — | 1 | 9.52 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418492 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 1.3 | nM | 8.89 |