Assay Detail
Binding
CHEMBL857524
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Tested for inhibitory activity against thymidylate synthase of L1210 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.74 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320217 | — | — | 1 | 9.77 |
| CHEMBL102143 | — | — | 1 | 9.70 |
| CHEMBL323098 | — | — | 1 | 9.48 |
| CHEMBL320450 | — | — | 1 | 9.38 |
| CHEMBL103105 | — | — | 1 | 9.15 |
| CHEMBL55437 | — | — | 1 | 9.11 |
| CHEMBL320651 | — | — | 1 | 8.68 |
| CHEMBL317717 | — | — | 1 | 8.46 |
| CHEMBL422395 | — | — | 1 | 7.70 |
| CHEMBL102954 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320217 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL102143 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL323098 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL320450 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL103105 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL55437 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL320651 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL317717 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL422395 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL102954 | — | Ki | = | 1200.0 | nM | 5.92 |