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Assay Detail

CHEMBL857526

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Binding
Inhibition constant against human factor Xa
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors.
Chou YL, Davey DD, Eagen KA, Griedel BD, Karanjawala R, Phillips GB, Sacchi KL, Shaw KJ, Wu SC, Lentz D, Liang AM, Trinh L, Morrissey MM, Kochanny MJ.
Bioorg Med Chem Lett (2003) 13 : 507 -511
PubMed 12565961 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 59 7.49 9.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54237 — — 1 9.49
CHEMBL147645 — — 1 9.34
CHEMBL149421 — — 1 9.22
CHEMBL356112 — — 1 8.74
CHEMBL146079 — — 1 8.66
CHEMBL146207 — — 1 8.64
CHEMBL357709 — — 1 8.43
CHEMBL149756 — — 1 8.30
CHEMBL149764 — — 1 8.23
CHEMBL145839 — — 1 8.15
CHEMBL149393 — — 1 8.15
CHEMBL150063 — — 1 8.15
CHEMBL146641 — — 1 8.14
CHEMBL50024 — — 1 7.96
CHEMBL148687 — — 1 7.96
CHEMBL422844 — — 1 7.85
CHEMBL149787 — — 1 7.82
CHEMBL345940 — — 1 7.80
CHEMBL53011 — — 1 7.80
CHEMBL146149 — — 1 7.75
CHEMBL358275 — — 1 7.72
CHEMBL357971 — — 1 7.66
CHEMBL147573 — — 1 7.66
CHEMBL342806 — — 1 7.62
CHEMBL147518 — — 1 7.60
CHEMBL359219 — — 1 7.58
CHEMBL146184 — — 1 7.58
CHEMBL147982 — — 1 7.52
CHEMBL148458 — — 1 7.27
CHEMBL358135 — — 1 7.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54237 — Ki = 0.32 nM 9.49
CHEMBL147645 — Ki = 0.46 nM 9.34
CHEMBL149421 — Ki = 0.6 nM 9.22
CHEMBL356112 — Ki = 1.8 nM 8.74
CHEMBL146079 — Ki = 2.2 nM 8.66
CHEMBL146207 — Ki = 2.3 nM 8.64
CHEMBL357709 — Ki = 3.7 nM 8.43
CHEMBL149756 — Ki = 5.0 nM 8.30
CHEMBL149764 — Ki = 5.9 nM 8.23
CHEMBL145839 — Ki = 7.0 nM 8.15
CHEMBL149393 — Ki = 7.1 nM 8.15
CHEMBL150063 — Ki = 7.0 nM 8.15
CHEMBL146641 — Ki = 7.2 nM 8.14
CHEMBL148687 — Ki = 11.0 nM 7.96
CHEMBL50024 — Ki = 11.0 nM 7.96
CHEMBL422844 — Ki = 14.0 nM 7.85
CHEMBL149787 — Ki = 15.0 nM 7.82
CHEMBL345940 — Ki = 16.0 nM 7.80
CHEMBL53011 — Ki = 16.0 nM 7.80
CHEMBL146149 — Ki = 18.0 nM 7.75
CHEMBL358275 — Ki = 19.0 nM 7.72
CHEMBL357971 — Ki = 22.0 nM 7.66
CHEMBL147573 — Ki = 22.0 nM 7.66
CHEMBL342806 — Ki = 24.0 nM 7.62
CHEMBL147518 — Ki = 25.0 nM 7.60
CHEMBL359219 — Ki = 26.0 nM 7.58
CHEMBL146184 — Ki = 26.0 nM 7.58
CHEMBL147982 — Ki = 30.0 nM 7.52
CHEMBL148458 — Ki = 54.0 nM 7.27
CHEMBL358135 — Ki = 58.0 nM 7.24
CHEMBL146365 — Ki = 73.0 nM 7.14
CHEMBL358610 — Ki = 78.0 nM 7.11
CHEMBL149657 — Ki = 100.0 nM 7.00
CHEMBL149875 — Ki = 130.0 nM 6.89
CHEMBL148917 — Ki = 150.0 nM 6.82
CHEMBL148791 — Ki = 160.0 nM 6.80
CHEMBL146592 — Ki = 210.0 nM 6.68
CHEMBL342733 — Ki = 210.0 nM 6.68
CHEMBL342551 — Ki = 260.0 nM 6.58
CHEMBL149006 — Ki = 280.0 nM 6.55
CHEMBL146511 — Ki = 390.0 nM 6.41
CHEMBL422134 — Ki = 470.0 nM 6.33
CHEMBL345769 — Ki = 590.0 nM 6.23
CHEMBL347983 — Ki = 960.0 nM 6.02
CHEMBL148036 — Ki = 1400.0 nM 5.85
CHEMBL149718 — Ki = 4400.0 nM 5.36
CHEMBL150216 — Ki = 4700.0 nM 5.33
CHEMBL356132 — Ki > 5000.0 nM -
CHEMBL146160 — Ki > 5000.0 nM -
CHEMBL148587 — Ki > 5000.0 nM -