Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL857541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Neuronal nitric oxide synthase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Nitric oxide synthase 1 (CHEMBL3568)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.
Moormann AE, Metz S, Toth MV, Moore WM, Jerome G, Kornmeier C, Manning P, Hansen DW, Pitzele BS, Webber RK.
Bioorg Med Chem Lett (2001) 11 : 2651 -2654
PubMed 11551770 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.33 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315194 1 6.47
CHEMBL89288 1 6.07
CHEMBL92475 1 6.03
CHEMBL89459 1 5.47
CHEMBL315857 1 5.46
CHEMBL314727 1 5.21
CHEMBL88308 1 5.17
CHEMBL89735 1 5.08
CHEMBL329431 1 4.99
CHEMBL330548 1 4.75
CHEMBL92422 1 4.68
CHEMBL89282 1 4.59
CHEMBL89431 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315194 IC50 = 339.0 nM 6.47
CHEMBL89288 IC50 = 850.0 nM 6.07
CHEMBL92475 IC50 = 932.0 nM 6.03
CHEMBL89459 IC50 = 3390.0 nM 5.47
CHEMBL315857 IC50 = 3500.0 nM 5.46
CHEMBL314727 IC50 = 6240.0 nM 5.21
CHEMBL88308 IC50 = 6800.0 nM 5.17
CHEMBL89735 IC50 = 8390.0 nM 5.08
CHEMBL329431 IC50 = 10150.0 nM 4.99
CHEMBL330548 IC50 = 17740.0 nM 4.75
CHEMBL92422 IC50 = 21000.0 nM 4.68
CHEMBL89282 IC50 = 25900.0 nM 4.59
CHEMBL89431 IC50 = 108000.0 nM -