Assay Detail
Binding
CHEMBL857543
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Inhibition of Na+/K+ ATPase from dog kidney
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium/potassium-transporting ATPase subunit alpha-1 (CHEMBL4838) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Synthesis, cardiotonic activity, and structure-activity relationships of 17 beta-guanylhydrazone derivatives of 5 beta-androstane-3 beta, 14 beta-diol acting on the Na+,K(+)-ATPase receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068996 | — | — | 1 | 6.80 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.30 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 6.30 |
| CHEMBL2068885 | — | — | 1 | 5.80 |
| CHEMBL2069057 | — | — | 1 | 5.70 |
| CHEMBL2068935 | — | — | 1 | 5.60 |
| CHEMBL2069128 | — | — | 1 | 5.40 |
| CHEMBL2068992 | — | — | 1 | 5.30 |
| CHEMBL2068940 | — | — | 1 | 5.20 |
| CHEMBL2068942 | — | — | 1 | 5.20 |
| CHEMBL2068936 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068996 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2068885 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2069057 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2068935 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2069128 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL2068992 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2068940 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL2068942 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL2068936 | — | IC50 | = | 7940.0 | nM | 5.10 |