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Assay Detail

CHEMBL857550

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Binding
Human Neuropeptide Y5 receptor binding affinity
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Neuropeptide Y receptor type 5 (CHEMBL4561)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists.
Galiano S, Erviti O, Pérez S, Moreno A, Juanenea L, Aldana I, Monge A.
Bioorg Med Chem Lett (2004) 14 : 597 -599
PubMed 14741250 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.42 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL17645 CGP-71683A 1 8.54
CHEMBL152016 1 8.11
CHEMBL155553 1 7.94
CHEMBL157157 1 7.90
CHEMBL154889 1 7.69
CHEMBL153522 1 7.55
CHEMBL422150 1 7.49
CHEMBL158344 1 7.37
CHEMBL154168 1 7.32
CHEMBL439638 1 7.32
CHEMBL350684 1 7.04
CHEMBL155048 1 6.85
CHEMBL157905 1 6.83
CHEMBL154412 1 6.76
CHEMBL440735 1 6.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL17645 CGP-71683A IC50 = 2.9 nM 8.54
CHEMBL152016 IC50 = 7.7 nM 8.11
CHEMBL155553 IC50 = 11.5 nM 7.94
CHEMBL157157 IC50 = 12.5 nM 7.90
CHEMBL154889 IC50 = 20.4 nM 7.69
CHEMBL153522 IC50 = 28.4 nM 7.55
CHEMBL422150 IC50 = 32.2 nM 7.49
CHEMBL158344 IC50 = 42.9 nM 7.37
CHEMBL154168 IC50 = 47.7 nM 7.32
CHEMBL439638 IC50 = 48.4 nM 7.32
CHEMBL350684 IC50 = 92.2 nM 7.04
CHEMBL155048 IC50 = 142.0 nM 6.85
CHEMBL157905 IC50 = 147.0 nM 6.83
CHEMBL154412 IC50 = 175.0 nM 6.76
CHEMBL440735 IC50 = 279.0 nM 6.55