Assay Detail
Binding
CHEMBL857566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M3) in Rat Submaxillary Gland
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL320) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and biological activity of some 4-DAMP- related compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.90 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | — | 1 | 8.94 |
| CHEMBL306182 | — | — | 1 | 8.53 |
| CHEMBL292857 | — | — | 2 | 7.98 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | Ki | = | 1.148 | nM | 8.94 |
| CHEMBL306182 | — | Ki | = | 2.951 | nM | 8.53 |
| CHEMBL292857 | — | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL292857 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 173.78 | nM | 6.76 |