Assay Detail
Functional
CHEMBL857762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth of HCT116 tumor cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.78 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59785 | — | — | 1 | 6.58 |
| CHEMBL62253 | — | — | 1 | 6.12 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.07 |
| CHEMBL61790 | — | — | 1 | 5.78 |
| CHEMBL64742 | — | — | 1 | 5.75 |
| CHEMBL64758 | — | — | 1 | 5.65 |
| CHEMBL293898 | — | — | 1 | 5.63 |
| CHEMBL291402 | — | — | 1 | 5.61 |
| CHEMBL302854 | — | — | 1 | 5.58 |
| CHEMBL293157 | — | — | 1 | 5.45 |
| CHEMBL292021 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59785 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL62253 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL61790 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL64742 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL64758 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL293898 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL291402 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL302854 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL293157 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL292021 | — | IC50 | = | 4540.0 | nM | 5.34 |