Assay Detail
Binding
CHEMBL857783
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Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-A receptor in rat pancreas
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1,5-Benzodiazepines as CCK-B antagonists. Effect of halogen substitution at the benzo-fused ring on potency and selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.15 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103750 | — | — | 1 | 8.81 |
| CHEMBL319795 | — | — | 1 | 8.34 |
| CHEMBL103968 | — | — | 1 | 8.31 |
| CHEMBL317081 | — | — | 1 | 8.05 |
| CHEMBL102867 | — | — | 1 | 8.01 |
| CHEMBL101125 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103750 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL319795 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL103968 | — | Ki | = | 4.898 | nM | 8.31 |
| CHEMBL317081 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL102867 | — | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL101125 | — | Ki | = | 41.69 | nM | 7.38 |