Assay Detail
Binding
CHEMBL857792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.53 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 8.71 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 8.70 |
| CHEMBL64875 | — | — | 1 | 8.69 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 8.64 |
| CHEMBL333955 | — | — | 1 | 7.85 |
| CHEMBL121274 | — | — | 1 | 7.84 |
| CHEMBL368324 | — | — | 1 | 7.79 |
| CHEMBL118889 | — | — | 1 | 7.74 |
| CHEMBL116542 | — | — | 1 | 7.70 |
| CHEMBL2111781 | — | — | 1 | 7.66 |
| CHEMBL120512 | — | — | 1 | 7.57 |
| CHEMBL119687 | — | — | 1 | 7.57 |
| CHEMBL333455 | — | — | 1 | 7.51 |
| CHEMBL118092 | — | — | 1 | 7.27 |
| CHEMBL2111783 | — | — | 2 | 7.22 |
| CHEMBL118919 | — | — | 1 | 7.14 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.07 |
| CHEMBL2111782 | — | — | 2 | 6.86 |
| CHEMBL333246 | — | — | 1 | 6.67 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.50 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL93240 | METITEPINE | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL64875 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL64249 | CLOROTEPINE | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL333955 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL121274 | — | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL368324 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL118889 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL116542 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2111781 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL120512 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL119687 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL333455 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL118092 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL2111783 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL2111783 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL118919 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL715 | OLANZAPINE | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL2111782 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL2111782 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL333246 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL42 | CLOZAPINE | Ki | = | 354.81 | nM | 6.45 |