Assay Detail
Binding
CHEMBL857793
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Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73665 | — | — | 1 | 7.00 |
| CHEMBL423671 | — | — | 1 | 6.80 |
| CHEMBL294747 | — | — | 1 | 6.40 |
| CHEMBL71960 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73665 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL423671 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL294747 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL71960 | — | Ki | = | 501.19 | nM | 6.30 |