Assay Detail
Binding
CHEMBL857876
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Binding affinity for human Platelet Thromboxane A2 / Prostaglandin (TP), by radioligand competition binding assays using [3H]-SQ 29548 as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.83 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308351 | — | — | 1 | 7.33 |
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 6.79 |
| CHEMBL122757 | — | — | 1 | 6.75 |
| CHEMBL123596 | — | — | 1 | 6.73 |
| CHEMBL122992 | — | — | 1 | 6.45 |
| CHEMBL122990 | — | — | 1 | 6.00 |
| CHEMBL332964 | — | — | 1 | 5.83 |
| CHEMBL121704 | — | — | 1 | 5.27 |
| CHEMBL121964 | — | — | 1 | 4.72 |
| CHEMBL120278 | — | — | 1 | 4.22 |
| CHEMBL333438 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308351 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL174984 | TRETOQUINOL | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL122757 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL123596 | — | Ki | = | 186.21 | nM | 6.73 |
| CHEMBL122992 | — | Ki | = | 354.81 | nM | 6.45 |
| CHEMBL122990 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL332964 | — | Ki | = | 1479.11 | nM | 5.83 |
| CHEMBL121704 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL121964 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL120278 | — | Ki | = | 60255.96 | nM | 4.22 |
| CHEMBL333438 | — | Ki | = | 83176.38 | nM | 4.08 |