Assay Detail
Binding
CHEMBL857984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.71 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41389 | — | — | 1 | 8.40 |
| CHEMBL289436 | — | — | 1 | 8.00 |
| CHEMBL276140 | — | — | 1 | 7.90 |
| CHEMBL41792 | — | — | 1 | 7.80 |
| CHEMBL297784 | — | — | 1 | 7.60 |
| CHEMBL44015 | — | — | 1 | 7.50 |
| CHEMBL297445 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41389 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL289436 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL276140 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL41792 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL297784 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL44015 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL297445 | — | Ki | = | 158.49 | nM | 6.80 |