Assay Detail
Binding
CHEMBL857994
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In vitro binding affinity towards Alpha-1 adrenergic receptor in rat cortex was determined using [3H]prazosin as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.33 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.09 |
| CHEMBL133188 | — | — | 1 | 7.81 |
| CHEMBL131011 | — | — | 1 | 7.75 |
| CHEMBL130276 | — | — | 1 | 7.66 |
| CHEMBL131900 | — | — | 1 | 7.56 |
| CHEMBL341390 | — | — | 1 | 7.19 |
| CHEMBL49247 | — | — | 1 | 6.84 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.74 |
| CHEMBL127216 | — | — | 1 | 6.68 |
| CHEMBL38288 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL133188 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL131011 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL130276 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL131900 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL341390 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL49247 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL13647 | BMY-7378 | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL127216 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL38288 | — | Ki | = | 1148.15 | nM | 5.94 |