Assay Detail
Binding
CHEMBL858025
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against dopamine receptor D1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.34 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | 2.0 | 1 | 7.85 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.55 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.45 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.12 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.94 |
| CHEMBL63756 | FLUPERLAPINE | 2.0 | 1 | 6.85 |
| CHEMBL67284 | ISOCLOTHIAPINE | — | 1 | 6.62 |
| CHEMBL147463 | — | — | 1 | 6.52 |
| CHEMBL433744 | — | — | 1 | 6.17 |
| CHEMBL151809 | — | — | 1 | 6.12 |
| CHEMBL149240 | — | — | 1 | 5.97 |
| CHEMBL356076 | — | — | 1 | 5.79 |
| CHEMBL146741 | — | — | 1 | 5.62 |
| CHEMBL435441 | — | — | 1 | 5.09 |
| CHEMBL149108 | — | — | 1 | 5.04 |
| CHEMBL151263 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL42 | CLOZAPINE | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL63756 | FLUPERLAPINE | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL67284 | ISOCLOTHIAPINE | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL147463 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL433744 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL151809 | — | Ki | = | 758.58 | nM | 6.12 |
| CHEMBL149240 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL356076 | — | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL146741 | — | Ki | = | 2398.83 | nM | 5.62 |
| CHEMBL435441 | — | Ki | = | 8128.31 | nM | 5.09 |
| CHEMBL149108 | — | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL151263 | — | Ki | = | 15488.17 | nM | 4.81 |