Assay Detail
Functional
CHEMBL858096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.77 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70751 | — | — | 1 | 8.55 |
| CHEMBL72768 | — | — | 1 | 8.25 |
| CHEMBL72724 | — | — | 1 | 8.10 |
| CHEMBL72441 | — | — | 1 | 8.05 |
| CHEMBL540035 | — | — | 1 | 7.55 |
| CHEMBL306792 | — | — | 1 | 7.00 |
| CHEMBL74114 | — | — | 1 | 6.35 |
| CHEMBL70634 | — | — | 1 | 6.10 |
| CHEMBL71479 | — | — | 1 | 5.95 |
| CHEMBL74467 | — | — | 1 | 5.70 |
| CHEMBL72958 | NS-49 | — | 1 | 5.70 |
| CHEMBL544290 | — | — | 1 | 5.50 |
| CHEMBL70740 | — | — | 1 | 5.20 |
| CHEMBL302698 | — | — | 1 | - |
| CHEMBL70563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70751 | — | EC50 | = | 2.818 | nM | 8.55 |
| CHEMBL72768 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL72724 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL72441 | — | EC50 | = | 8.913 | nM | 8.05 |
| CHEMBL540035 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL306792 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL74114 | — | EC50 | = | 446.68 | nM | 6.35 |
| CHEMBL70634 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL71479 | — | EC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL74467 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL72958 | NS-49 | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL544290 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL70740 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL302698 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL70563 | — | EC50 | < | 10000.0 | nM | - |