Assay Detail

CHEMBL858235

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Functional

Inhibition of replication of R5 HIV1 CTV in PMBC

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.

Seto M, Aikawa K, Miyamoto N, Aramaki Y, Kanzaki N, Takashima K, Kuze Y, Iizawa Y, Baba M, Shiraishi M.
J Med Chem (2006) 49 : 2037 -2048
PubMed 16539392 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.15	10.15
IC90	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2105686	CENICRIVIROC MESYLATE	1.0	2	10.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2105686	CENICRIVIROC MESYLATE	IC50	=	0.07	nM	10.15
CHEMBL2105686	CENICRIVIROC MESYLATE	IC90	=	0.31	nM	-