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Assay Detail

CHEMBL858253

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Binding
Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)
ChEMBL ↗
111
Total Activities
110
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type RBL-1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.
Summers JB, Kim KH, Mazdiyasni H, Holms JH, Ratajczyk JD, Stewart AO, Dyer RD, Carter GW.
J Med Chem (1990) 33 : 992 -998
PubMed 2308149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 111 5.83 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65655 — — 1 7.70
CHEMBL351785 — — 1 7.30
CHEMBL65654 — — 1 7.22
CHEMBL177549 — — 1 7.15
CHEMBL367336 — — 1 7.10
CHEMBL368826 — — 1 7.00
CHEMBL368604 — — 1 7.00
CHEMBL63882 — — 1 7.00
CHEMBL446362 — — 1 7.00
CHEMBL351338 — — 1 7.00
CHEMBL368764 — — 1 6.96
CHEMBL155033 — — 1 6.96
CHEMBL367913 — — 1 6.92
CHEMBL154200 — — 1 6.92
CHEMBL154575 — — 1 6.89
CHEMBL178053 — — 1 6.89
CHEMBL177476 — — 1 6.89
CHEMBL94394 BUFEXAMAC 4.0 1 6.89
CHEMBL152665 PHENYLACETOHYDROXAMIC ACID — 1 6.80
CHEMBL156887 — — 1 6.74
CHEMBL175134 — — 1 6.68
CHEMBL154843 — — 1 6.68
CHEMBL69110 — — 1 6.55
CHEMBL177661 — — 1 6.55
CHEMBL304443 — — 1 6.54
CHEMBL65430 — — 1 6.54
CHEMBL177594 — — 1 6.52
CHEMBL174896 — — 1 6.51
CHEMBL154008 — — 1 6.48
CHEMBL176289 — — 1 6.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65655 — IC50 = 19.95 nM 7.70
CHEMBL351785 — IC50 = 50.12 nM 7.30
CHEMBL65654 — IC50 = 60.26 nM 7.22
CHEMBL177549 — IC50 = 70.79 nM 7.15
CHEMBL367336 — IC50 = 79.43 nM 7.10
CHEMBL446362 — IC50 = 100.0 nM 7.00
CHEMBL63882 — IC50 = 100.0 nM 7.00
CHEMBL368604 — IC50 = 100.0 nM 7.00
CHEMBL351338 — IC50 = 100.0 nM 7.00
CHEMBL368826 — IC50 = 100.0 nM 7.00
CHEMBL368764 — IC50 = 109.65 nM 6.96
CHEMBL155033 — IC50 = 109.65 nM 6.96
CHEMBL154200 — IC50 = 120.23 nM 6.92
CHEMBL367913 — IC50 = 120.23 nM 6.92
CHEMBL154575 — IC50 = 128.82 nM 6.89
CHEMBL178053 — IC50 = 128.82 nM 6.89
CHEMBL177476 — IC50 = 128.82 nM 6.89
CHEMBL94394 BUFEXAMAC IC50 = 128.82 nM 6.89
CHEMBL152665 PHENYLACETOHYDROXAMIC ACID IC50 = 158.49 nM 6.80
CHEMBL156887 — IC50 = 181.97 nM 6.74
CHEMBL154843 — IC50 = 208.93 nM 6.68
CHEMBL175134 — IC50 = 208.93 nM 6.68
CHEMBL177661 — IC50 = 281.84 nM 6.55
CHEMBL69110 — IC50 = 281.84 nM 6.55
CHEMBL304443 — IC50 = 288.4 nM 6.54
CHEMBL65430 — IC50 = 288.4 nM 6.54
CHEMBL177594 — IC50 = 302.0 nM 6.52
CHEMBL174896 — IC50 = 309.03 nM 6.51
CHEMBL154008 — IC50 = 331.13 nM 6.48
CHEMBL176289 — IC50 = 338.84 nM 6.47
CHEMBL174051 — IC50 = 363.08 nM 6.44
CHEMBL367401 — IC50 = 380.19 nM 6.42
CHEMBL67411 — IC50 = 407.38 nM 6.39
CHEMBL177702 — IC50 = 407.38 nM 6.39
CHEMBL67940 — IC50 = 446.68 nM 6.35
CHEMBL174161 — IC50 = 467.74 nM 6.33
CHEMBL177392 — IC50 = 489.78 nM 6.31
CHEMBL155611 — IC50 = 512.86 nM 6.29
CHEMBL146477 — IC50 = 588.84 nM 6.23
CHEMBL367293 — IC50 = 645.65 nM 6.19
CHEMBL177499 — IC50 = 676.08 nM 6.17
CHEMBL68235 — IC50 = 724.44 nM 6.14
CHEMBL303900 — IC50 = 758.58 nM 6.12
CHEMBL303033 — IC50 = 776.25 nM 6.11
CHEMBL177989 — IC50 = 776.25 nM 6.11
CHEMBL366840 — IC50 = 831.76 nM 6.08
CHEMBL307568 — IC50 = 851.14 nM 6.07
CHEMBL178065 — IC50 = 891.25 nM 6.05
CHEMBL366714 — IC50 = 954.99 nM 6.02
CHEMBL155443 — IC50 = 954.99 nM 6.02