Assay Detail
Binding
CHEMBL858658
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Inhibitory activity against COMT in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.32 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197115 | — | — | 1 | 5.52 |
| CHEMBL198628 | — | — | 1 | 5.40 |
| CHEMBL8476 | — | — | 1 | 5.40 |
| CHEMBL8649 | — | — | 1 | 5.40 |
| CHEMBL953 | ENTACAPONE | 4.0 | 1 | 4.89 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | - |
| CHEMBL160038 | NEBICAPONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197115 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL198628 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL8476 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL8649 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL953 | ENTACAPONE | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1324 | TOLCAPONE | IC50 | = | 2200.0 | nM | - |
| CHEMBL160038 | NEBICAPONE | IC50 | = | 3700.0 | nM | - |