Assay Detail
Binding
CHEMBL858762
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Inhibition of Dihydrofolate reductase from Lactobacillus casei
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 4.71 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265493 | — | — | 1 | 5.20 |
| CHEMBL334565 | — | — | 1 | 5.02 |
| CHEMBL132812 | — | — | 1 | 5.02 |
| CHEMBL135984 | — | — | 1 | 5.02 |
| CHEMBL135424 | — | — | 1 | 5.00 |
| CHEMBL342714 | — | — | 1 | 5.00 |
| CHEMBL336639 | — | — | 1 | 4.94 |
| CHEMBL135459 | — | — | 1 | 4.87 |
| CHEMBL135854 | — | — | 1 | 4.74 |
| CHEMBL335498 | — | — | 1 | 4.70 |
| CHEMBL135987 | — | — | 1 | 4.55 |
| CHEMBL135777 | — | — | 1 | 4.45 |
| CHEMBL136925 | — | — | 1 | 4.10 |
| CHEMBL336725 | — | — | 1 | 4.07 |
| CHEMBL132703 | — | — | 1 | 4.00 |
| CHEMBL137456 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265493 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL334565 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL132812 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL135984 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL135424 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL342714 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL336639 | — | Ki | = | 11481.54 | nM | 4.94 |
| CHEMBL135459 | — | Ki | = | 13489.63 | nM | 4.87 |
| CHEMBL135854 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL335498 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL135987 | — | Ki | = | 28183.83 | nM | 4.55 |
| CHEMBL135777 | — | Ki | = | 35481.34 | nM | 4.45 |
| CHEMBL136925 | — | Ki | = | 79432.82 | nM | 4.10 |
| CHEMBL336725 | — | Ki | = | 85113.8 | nM | 4.07 |
| CHEMBL132703 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL137456 | — | Ki | = | 109647.82 | nM | - |