Assay Detail
Binding
CHEMBL858783
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Inhibitory activity against recombinant CDC25C
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.61 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199359 | — | — | 1 | 6.89 |
| CHEMBL382593 | — | — | 1 | 6.89 |
| CHEMBL373195 | — | — | 1 | 6.82 |
| CHEMBL199360 | — | — | 1 | 6.64 |
| CHEMBL200805 | — | — | 1 | 6.64 |
| CHEMBL337173 | — | — | 1 | 6.60 |
| CHEMBL437898 | — | — | 2 | 4.92 |
| CHEMBL380820 | — | — | 1 | 4.92 |
| CHEMBL201497 | — | — | 1 | 4.92 |
| CHEMBL200800 | — | — | 2 | 4.77 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.72 |
| CHEMBL200331 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199359 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL382593 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL373195 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL199360 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL200805 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL337173 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL437898 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL437898 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL380820 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL201497 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL200800 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL200800 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL590 | MENADIONE | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL200331 | — | IC50 | = | 81000.0 | nM | 4.09 |