Assay Detail
Binding
CHEMBL858790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.03 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197595 | — | — | 1 | 8.34 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 7.72 |
| CHEMBL201488 | — | — | 1 | - |
| CHEMBL201314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197595 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL409 | BICALUTAMIDE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL201488 | — | Ki | - | — | - | |
| CHEMBL201314 | — | Ki | - | — | - |