Assay Detail
Binding
CHEMBL859108
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Binding affinity to human ERbeta
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Androstenediol analogs as ER-beta-selective SERMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.05 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.92 |
| CHEMBL440283 | ANDROSTENEDIOL | -1.0 | 1 | 8.00 |
| CHEMBL373019 | — | — | 1 | 7.96 |
| CHEMBL381566 | — | — | 1 | 7.85 |
| CHEMBL382097 | — | — | 1 | 7.80 |
| CHEMBL383253 | — | — | 1 | 7.80 |
| CHEMBL437065 | — | — | 1 | 7.77 |
| CHEMBL202400 | — | — | 1 | 7.66 |
| CHEMBL204642 | — | — | 1 | 7.60 |
| CHEMBL202007 | — | — | 1 | 7.60 |
| CHEMBL201569 | — | — | 1 | 7.08 |
| CHEMBL202415 | — | — | 1 | 7.02 |
| CHEMBL370236 | — | — | 1 | 6.91 |
| CHEMBL369979 | — | — | 1 | 6.89 |
| CHEMBL201517 | — | — | 1 | 6.88 |
| CHEMBL204317 | — | — | 1 | 6.68 |
| CHEMBL379441 | — | — | 1 | 6.67 |
| CHEMBL380978 | — | — | 1 | 6.64 |
| CHEMBL203561 | — | — | 1 | 6.54 |
| CHEMBL380876 | — | — | 1 | 6.52 |
| CHEMBL369991 | — | — | 1 | 6.44 |
| CHEMBL201809 | — | — | 1 | 6.42 |
| CHEMBL203748 | — | — | 1 | 6.11 |
| CHEMBL204389 | — | — | 1 | 5.89 |
| CHEMBL201364 | — | — | 1 | 5.79 |
| CHEMBL382632 | — | — | 1 | 5.76 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL440283 | ANDROSTENEDIOL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL373019 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL381566 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL382097 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL383253 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL437065 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL202400 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL204642 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL202007 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL201569 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL202415 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL370236 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL369979 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL201517 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL204317 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL379441 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL380978 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL203561 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL380876 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL369991 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL201809 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL203748 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL204389 | — | IC50 | = | 1299.0 | nM | 5.89 |
| CHEMBL201364 | — | IC50 | = | 1619.0 | nM | 5.79 |
| CHEMBL382632 | — | IC50 | = | 1754.0 | nM | 5.76 |
| CHEMBL386630 | TESTOSTERONE | IC50 | > | 10000.0 | nM | - |