Assay Detail
Functional
CHEMBL859110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on transactivation of ALP gene expression in HEK293 cells transfected with hERalpha
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Androstenediol analogs as ER-beta-selective SERMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.58 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.12 |
| CHEMBL381566 | — | — | 1 | 8.00 |
| CHEMBL440283 | ANDROSTENEDIOL | -1.0 | 1 | 7.58 |
| CHEMBL202415 | — | — | 1 | 7.33 |
| CHEMBL437065 | — | — | 1 | 6.80 |
| CHEMBL202400 | — | — | 1 | 6.49 |
| CHEMBL383253 | — | — | 1 | 6.46 |
| CHEMBL204642 | — | — | 1 | 6.31 |
| CHEMBL204389 | — | — | 1 | 6.23 |
| CHEMBL370236 | — | — | 1 | 6.22 |
| CHEMBL202007 | — | — | 1 | 6.21 |
| CHEMBL369991 | — | — | 1 | 6.14 |
| CHEMBL380978 | — | — | 1 | 6.07 |
| CHEMBL373019 | — | — | 1 | 6.01 |
| CHEMBL203561 | — | — | 1 | 6.01 |
| CHEMBL369979 | — | — | 1 | 6.00 |
| CHEMBL201809 | — | — | 1 | 6.00 |
| CHEMBL380876 | — | — | 1 | 5.49 |
| CHEMBL201364 | — | — | 1 | - |
| CHEMBL203748 | — | — | 1 | - |
| CHEMBL204317 | — | — | 1 | - |
| CHEMBL379441 | — | — | 1 | - |
| CHEMBL382632 | — | — | 1 | - |
| CHEMBL201569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL381566 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL440283 | ANDROSTENEDIOL | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL202415 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL437065 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL202400 | — | EC50 | = | 324.0 | nM | 6.49 |
| CHEMBL383253 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL204642 | — | EC50 | = | 494.0 | nM | 6.31 |
| CHEMBL204389 | — | EC50 | = | 583.0 | nM | 6.23 |
| CHEMBL370236 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL202007 | — | EC50 | = | 622.0 | nM | 6.21 |
| CHEMBL369991 | — | EC50 | = | 719.0 | nM | 6.14 |
| CHEMBL380978 | — | EC50 | = | 844.0 | nM | 6.07 |
| CHEMBL373019 | — | EC50 | = | 982.0 | nM | 6.01 |
| CHEMBL203561 | — | EC50 | = | 984.0 | nM | 6.01 |
| CHEMBL369979 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL201809 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL380876 | — | EC50 | = | 3237.0 | nM | 5.49 |
| CHEMBL201364 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL203748 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL204317 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL379441 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL382632 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL201569 | — | EC50 | > | 1000.0 | nM | - |