Assay Detail
Functional
CHEMBL859115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human prostate carcinoma LNCaP cell line
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.52 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201380 | — | — | 1 | 6.44 |
| CHEMBL200132 | — | — | 1 | 6.35 |
| CHEMBL380823 | — | — | 1 | 6.31 |
| CHEMBL199601 | — | — | 1 | 6.17 |
| CHEMBL199604 | — | — | 1 | 6.10 |
| CHEMBL382137 | — | — | 1 | 6.03 |
| CHEMBL201238 | — | — | 1 | 5.98 |
| CHEMBL202978 | — | — | 1 | 5.97 |
| CHEMBL199953 | — | — | 1 | 5.92 |
| CHEMBL199332 | — | — | 1 | 5.88 |
| CHEMBL201487 | — | — | 1 | 5.87 |
| CHEMBL383608 | — | — | 1 | 5.81 |
| CHEMBL201590 | — | — | 1 | 5.80 |
| CHEMBL203140 | — | — | 1 | 5.76 |
| CHEMBL382849 | — | — | 1 | 5.75 |
| CHEMBL201345 | — | — | 1 | 5.73 |
| CHEMBL201704 | — | — | 1 | 5.72 |
| CHEMBL383649 | — | — | 1 | 5.70 |
| CHEMBL380751 | — | — | 1 | 5.66 |
| CHEMBL381044 | — | — | 1 | 5.64 |
| CHEMBL380657 | — | — | 1 | 5.62 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | — | 1 | 5.62 |
| CHEMBL201356 | — | — | 1 | 5.62 |
| CHEMBL201734 | — | — | 1 | 5.61 |
| CHEMBL369978 | — | — | 1 | 5.60 |
| CHEMBL201134 | — | — | 1 | 5.57 |
| CHEMBL198407 | — | — | 1 | 5.56 |
| CHEMBL377948 | — | — | 1 | 5.55 |
| CHEMBL201319 | — | — | 1 | 5.52 |
| CHEMBL202379 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201380 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL200132 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL380823 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL199601 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL199604 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL382137 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL201238 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL202978 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL199953 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL199332 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL201487 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL383608 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL201590 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL203140 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL382849 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL201345 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL201704 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL383649 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL380751 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL381044 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL380657 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL201356 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL201734 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL369978 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL201134 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL198407 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL377948 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL201319 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL202379 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL202778 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL440759 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL202664 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL199556 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL413570 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL199942 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL201545 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL201078 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL202975 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL381989 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL382802 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL202976 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL199889 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL370376 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL437138 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL381302 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL381859 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL201741 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL201123 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL381737 | — | IC50 | = | 6110.0 | nM | 5.21 |