Assay Detail
Functional
CHEMBL859150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against HIV-112 assessed by inhibition of p24 production in human lymphocytes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.31 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383700 | — | — | 1 | 8.22 |
| CHEMBL382230 | — | — | 1 | 8.10 |
| CHEMBL206990 | — | — | 1 | 7.52 |
| CHEMBL207361 | — | — | 1 | 7.52 |
| CHEMBL209228 | — | — | 1 | 7.40 |
| CHEMBL378236 | — | — | 1 | 7.30 |
| CHEMBL383724 | — | — | 1 | 6.40 |
| CHEMBL210336 | — | — | 1 | 6.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383700 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL382230 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL206990 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL207361 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL209228 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL378236 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL383724 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL210336 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | > | 20000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 20000.0 | nM | - |