Assay Detail
Functional
CHEMBL859207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.40 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105686 | CENICRIVIROC MESYLATE | 1.0 | 1 | 10.00 |
| CHEMBL3085308 | — | — | 1 | 9.72 |
| CHEMBL3085309 | — | — | 1 | 9.68 |
| CHEMBL3085307 | — | — | 1 | 9.62 |
| CHEMBL3085311 | — | — | 1 | 9.32 |
| CHEMBL3085310 | — | — | 1 | 9.02 |
| CHEMBL204821 | — | — | 1 | 9.00 |
| CHEMBL41275 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105686 | CENICRIVIROC MESYLATE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3085308 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3085309 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3085307 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3085311 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3085310 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL204821 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL41275 | — | IC50 | = | 1.4 | nM | 8.85 |