Assay Detail
Functional
CHEMBL859209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
11
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MOLT-4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.83 | 9.70 |
| IC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105686 | CENICRIVIROC MESYLATE | 1.0 | 2 | 9.70 |
| CHEMBL3085307 | — | — | 1 | 8.85 |
| CHEMBL3085311 | — | — | 2 | 8.68 |
| CHEMBL3085309 | — | — | 2 | 8.64 |
| CHEMBL204821 | — | — | 2 | 8.28 |
| CHEMBL3085308 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105686 | CENICRIVIROC MESYLATE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3085307 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3085311 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3085309 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL204821 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2105686 | CENICRIVIROC MESYLATE | IC90 | = | 0.81 | nM | - |
| CHEMBL204821 | — | IC90 | = | 860.0 | nM | - |
| CHEMBL3085311 | — | IC90 | = | 19.0 | nM | - |
| CHEMBL3085309 | — | IC90 | = | 11.0 | nM | - |
| CHEMBL3085308 | — | IC50 | < | 1.6 | nM | - |
| CHEMBL3085308 | — | IC90 | = | 10.0 | nM | - |