Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL859293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Expert

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Coro J, Atherton R, Little S, Wharton H, Yardley V, Alvarez A, Súarez M, Pérez R, Rodríguez H.
Bioorg Med Chem Lett (2006) 16 : 1312 -1315
PubMed 16343898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.95 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 1 7.96
CHEMBL203662 1 6.44
CHEMBL382040 1 6.43
CHEMBL383681 1 6.25
CHEMBL203648 1 6.14
CHEMBL380734 1 6.14
CHEMBL203702 1 6.03
CHEMBL203130 1 5.98
CHEMBL204817 1 5.64
CHEMBL264313 1 5.61
CHEMBL204546 1 5.54
CHEMBL204745 1 5.44
CHEMBL204953 1 5.37
CHEMBL425763 1 5.27
CHEMBL203490 1 5.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE IC50 = 11.0 nM 7.96
CHEMBL203662 IC50 = 360.0 nM 6.44
CHEMBL382040 IC50 = 370.0 nM 6.43
CHEMBL383681 IC50 = 560.0 nM 6.25
CHEMBL203648 IC50 = 730.0 nM 6.14
CHEMBL380734 IC50 = 730.0 nM 6.14
CHEMBL203702 IC50 = 930.0 nM 6.03
CHEMBL203130 IC50 = 1040.0 nM 5.98
CHEMBL204817 IC50 = 2300.0 nM 5.64
CHEMBL264313 IC50 = 2480.0 nM 5.61
CHEMBL204546 IC50 = 2880.0 nM 5.54
CHEMBL204745 IC50 = 3600.0 nM 5.44
CHEMBL204953 IC50 = 4270.0 nM 5.37
CHEMBL425763 IC50 = 5340.0 nM 5.27
CHEMBL203490 IC50 = 9370.0 nM 5.03