Assay Detail
Functional
CHEMBL859501
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Cytotoxicity against HCT116 human colon cancer cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.99 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200899 | CALLYSTATIN A | — | 1 | 10.52 |
| CHEMBL200280 | — | — | 1 | 9.70 |
| CHEMBL200306 | — | — | 1 | 8.70 |
| CHEMBL200808 | — | — | 1 | 8.52 |
| CHEMBL372123 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200899 | CALLYSTATIN A | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL200280 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL200306 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL200808 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL372123 | — | IC50 | = | 30.0 | nM | 7.52 |