Assay Detail
Binding
CHEMBL859540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against DPP4
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.66 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307636 | — | — | 1 | 7.92 |
| CHEMBL201644 | — | — | 1 | 7.82 |
| CHEMBL425756 | — | — | 1 | 7.66 |
| CHEMBL380902 | — | — | 1 | 7.52 |
| CHEMBL201424 | — | — | 1 | 7.31 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.29 |
| CHEMBL77538 | — | — | 1 | 7.28 |
| CHEMBL425585 | — | — | 1 | 7.27 |
| CHEMBL203084 | — | — | 1 | 7.08 |
| CHEMBL200103 | — | — | 1 | 6.94 |
| CHEMBL201158 | — | — | 1 | 6.92 |
| CHEMBL381530 | — | — | 1 | 6.88 |
| CHEMBL371480 | — | — | 1 | 6.53 |
| CHEMBL203032 | — | — | 1 | 6.50 |
| CHEMBL382847 | — | — | 1 | 6.43 |
| CHEMBL371057 | — | — | 1 | 6.37 |
| CHEMBL201695 | — | — | 1 | 6.35 |
| CHEMBL382907 | — | — | 1 | 6.34 |
| CHEMBL383841 | — | — | 1 | 6.28 |
| CHEMBL201544 | — | — | 1 | 6.25 |
| CHEMBL424854 | — | — | 1 | 6.19 |
| CHEMBL372746 | — | — | 1 | 6.17 |
| CHEMBL372391 | — | — | 1 | 6.11 |
| CHEMBL201398 | — | — | 1 | 6.09 |
| CHEMBL202711 | — | — | 1 | 5.96 |
| CHEMBL201753 | — | — | 1 | 5.85 |
| CHEMBL98408 | — | — | 1 | 5.78 |
| CHEMBL371907 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307636 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL201644 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL425756 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL380902 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL201424 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL77538 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL425585 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL203084 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL200103 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL201158 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL381530 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL371480 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL203032 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL382847 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL371057 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL201695 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL382907 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL383841 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL201544 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL424854 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL372746 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL372391 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL201398 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL202711 | — | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL201753 | — | IC50 | = | 1418.0 | nM | 5.85 |
| CHEMBL98408 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL371907 | — | IC50 | = | 3236.0 | nM | 5.49 |