Compound Detail
CHEMBL371907
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Basic Information
| ChEMBL ID | CHEMBL371907 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HGLYHGKGQIVSLQ-INIZCTEOSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
326.4
MW (Da)
0.68
ALogP
4
HBA
1
HBD
76.4
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 5.49 | 5.485 | 3236.0 | 2 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 5.38 | 5.38 | 4169.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 3236.0 | nM | 5.49 | Inhibitory activity against DPP4 | 16392822 |
| Dipeptidyl peptidase 4 | IC50 | = | 3300.0 | nM | 5.48 | Inhibition of human DPP4 expressed in baculovirus system | 18207285 |
| Dipeptidyl peptidase 8 | IC50 | = | 4169.0 | nM | 5.38 | Inhibitory activity against DPP8 | 16392822 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16392822 | 10.1021/jm0507781 | Dipeptidyl peptidase 4 | 1 |
| 16392822 | 10.1021/jm0507781 | Dipeptidyl peptidase 8 | 1 |
| 16392822 | 10.1021/jm0507781 | Dipeptidyl peptidase 2 | 1 |
| 18207285 | 10.1016/j.ejmech.2007.11.014 | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine