Assay Detail
Binding
CHEMBL999374
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Inhibition of human DPP4 expressed in baculovirus system
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.91 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497992 | — | — | 1 | 8.59 |
| CHEMBL324777 | — | — | 1 | 8.05 |
| CHEMBL497993 | — | — | 1 | 7.96 |
| CHEMBL507254 | — | — | 1 | 7.92 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
| CHEMBL522909 | — | — | 1 | 7.68 |
| CHEMBL504823 | — | — | 1 | 7.68 |
| CHEMBL77538 | — | — | 1 | 7.66 |
| CHEMBL495932 | — | — | 1 | 7.60 |
| CHEMBL496131 | — | — | 1 | 7.37 |
| CHEMBL527015 | — | — | 1 | 7.35 |
| CHEMBL451319 | — | — | 1 | 7.16 |
| CHEMBL280658 | — | — | 1 | 7.14 |
| CHEMBL380860 | — | — | 1 | 6.96 |
| CHEMBL443250 | — | — | 1 | 6.77 |
| CHEMBL498167 | — | — | 1 | 6.60 |
| CHEMBL186406 | — | — | 1 | 6.50 |
| CHEMBL525183 | — | — | 1 | 6.43 |
| CHEMBL234412 | — | — | 1 | 6.15 |
| CHEMBL371907 | — | — | 1 | 5.48 |
| CHEMBL522911 | — | — | 1 | 4.92 |
| CHEMBL497782 | — | — | 1 | 4.89 |
| CHEMBL496953 | — | — | 1 | 4.30 |
| CHEMBL361235 | — | — | 1 | - |
| CHEMBL523066 | — | — | 1 | - |
| CHEMBL509777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497992 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL324777 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL497993 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL507254 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL522909 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL504823 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL77538 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL495932 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL496131 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL527015 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL451319 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL280658 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL380860 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL443250 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL498167 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL186406 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL525183 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL234412 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL371907 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL522911 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL497782 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL496953 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL361235 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL523066 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL509777 | — | IC50 | = | 390000.0 | nM | - |