Assay Detail
Functional
CHEMBL859606
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Agonism at 5HT4 receptor in rat tunica muscularis mucosa
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.19 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201621 | — | — | 1 | 8.82 |
| CHEMBL34291 | — | — | 1 | 7.78 |
| CHEMBL2448165 | — | — | 1 | 7.29 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 7.26 |
| CHEMBL2448558 | — | — | 1 | 7.01 |
| CHEMBL199866 | — | — | 1 | 6.89 |
| CHEMBL201019 | — | — | 1 | 6.71 |
| CHEMBL37333 | — | — | 1 | 6.49 |
| CHEMBL201414 | — | — | 1 | 6.43 |
| CHEMBL202434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201621 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL34291 | — | EC50 | = | 16.5 | nM | 7.78 |
| CHEMBL2448165 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1729 | CISAPRIDE | EC50 | = | 54.7 | nM | 7.26 |
| CHEMBL2448558 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL199866 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL201019 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL37333 | — | EC50 | = | 323.0 | nM | 6.49 |
| CHEMBL201414 | — | EC50 | = | 374.2 | nM | 6.43 |
| CHEMBL202434 | — | EC50 | > | 10000.0 | nM | - |